China Factory for Nadh Medicament - Transaminase (ATA) – SyncoZymes
China Factory for Nadh Medicament - Transaminase (ATA) – SyncoZymes Detail:
Enzymes: Are macromolecular biological catalysts, most enzymes are proteins.
Transaminases: A class of enzymes that catalyze amino transferring between amino acids and keto acids. Transaminases are key biological enzymes in asymmetric synthesis and racemic resolution of chiral amines.
Aminotransferase can be divided into four classes according to sequence and structure: Ⅰ, Ⅱ, Ⅲ and Ⅳ. ω-aminotransferases belong to class II transaminases, commonly be used in the preparation of chiral amines and unnatural amino acids, such as β-amino acids.
ω-aminotransferases: In most cases, ω-transaminase refers to a class of enzymes, that catalytic ammonia transfer reactions without α-amino acid as substrate or product.
Catalytic mechanism:
Enzymes | Product Code | Product Code |
Enzyme Powder | ES-ATA-101~ ES-ATA-165 | a set of 65 ω-Transaminases, 50 mg each 65 items * 50mg / item, or other quantity |
Screening Kit (SynKit) | ES-ATA-6500 | a set of 65 ω-Transaminases, 1 mg each 65 items * 1mg / item |
★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion efficiency.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Enzyme screening should be carried out for specific substrates because of the substrate specificity, and get an enzyme that catalyzes the target substrate with best catalytic effect.
➢ Never contact with extreme conditions such as: high temperature, high/low pH and organic solvent with high concentration.
➢ Normally, the reaction system should include substrate, buffer solution, amino donor (such as amino acids and 1-phenyl ethylamine) or receptor (such as keto acids), coenzyme (PLP), cosolvent (such as DMSO).
➢ ATA should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
➢ All kinds of ATA have various optimum reaction conditions, so each of them should be further studied individually.
Example 1(synthesis of Sitagliptin, asymmetric synthesis) (1):
Example 2 (Mexiletine, Combination of kinetic resolution with asymmetric synthesis)(2):
1 Savile CK, Janey JM, Mundorff EC, et al. Science, 2010, 329(16), 305-309.
2 Koszelewski D, Pressnitz D, Clay D, et al. Organic letters, 2009,11(21):4810-4812.
Product detail pictures:
Related Product Guide:
It adheres on the tenet "Honest, industrious, enterprising, innovative" to acquire new solutions continuously. It regards prospects, success as its personal success. Let us build prosperous future hand in hand for China Factory for Nadh Medicament - Transaminase (ATA) – SyncoZymes , The product will supply to all over the world, such as: Algeria, Czech republic, Georgia, It using the world's leading system for reliable operation, a low failure rate, it suitable for Argentina customers choice. Our company is situated within the national civilized cities, the traffic is very convenient, unique geographical and economic conditions. We pursue a people-oriented, meticulous manufacturing, brainstorm, build brilliant" business philosophy. Strict quality management, perfect service, reasonable price in Argentina is our stand on the premise of competition. If necessary, welcome to contact us by our website or phone consultation, we'll be happy to serve you.
By Madeline from Algeria - 2017.02.18 15:54
The factory workers have rich industry knowledge and operational experience, we learned a lot in working with them,we are extremely grateful that we can encount a good company has excellent wokers.
By Federico Michael Di Marco from Riyadh - 2018.12.10 19:03