Chinese Professional Cdmo Drug Development - Cyclooxygenase (COX) – SyncoZymes

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Chinese Professional Cdmo Drug Development - Cyclooxygenase (COX) – SyncoZymes Detail:

Catalytic reaction type:

Haloperoxidase:

Cyclooxygenase COX2

Styrene monooxygenase:

Cyclooxygenase COX3

Enzymes	Product Code	Specification
Enzyme Powder	ES-COX-101~ ES-COX-110	a set of 10 NADH Cyclooxygenase, 50 mg each 10 items * 50mg / item, or other quantity

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Normally, haloperoxidase reaction system includes: substrate, buffer, enzyme, H2O2 and halogen ion. Styrene monooxygenase reaction system includes substrate, buffer, enzyme, coenzyme and coenzyme regeneration system
➢ COX should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.

Example 1(Synthesis of epoxy styrene derivatives from styrene derivatives)⁽¹⁾:

Cyclooxygenase COX4

Note: application examples and references are intended to indicate the application scope of COX for ease of understanding, and do not correspond to the specific enzyme of SyncoZymes.

Keep 2 years below -20℃.

Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.

1. Lin, Hui, Yan Liu, and Zhong-Liu Wu. Tetrahedron: Asymmetry 22.2 (2011): 134-137.

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