Chinese Professional Cdmo Drug Development - Phenylalanine ammonia lyase (PAL) – SyncoZymes
Chinese Professional Cdmo Drug Development - Phenylalanine ammonia lyase (PAL) – SyncoZymes Detail:
| Enzymes | Product Code | Specification |
| Enzyme Powder | ES-PAL-101~ ES-PAL-110 | a set of 10 L-phenylalanine ammonia-lyase, 50 mg each 10 items * 50mg / item, or other quantity |
★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Normally, the reaction system should include substrate, buffer solution and enzyme.
➢ Each kind of ES-PAL corresponding to various optimum reaction conditions, which could be studied individually.
➢ The ES-PAL should be added last into reaction system to maintain the activity.
Example 1(Biosynthesis of trans cinnamic acid from phenylalanine) (1):
Example 2(Biosynthesis of phenylalanine derivative from trans-cinnamic acid derivative)(2):
Keep 2 years below -20℃.
Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.
1. Zachary Mays, Karishma Mohan, et al. Chem Commun (Camb). 2020, 56, 5255-5258.
2. Ian Rowles, Bas Groenendaal, et al. Tetrahedron, 2016. 72, 7343-7347.
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By Jerry from Philadelphia - 2017.10.27 12:12
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