SyncoZymes

products

High definition Morosil Com Nadh - Transaminase (ATA) – SyncoZymes

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

The key to our success is "Good Product Quality, Reasonable Price and Efficient Service" for Nicotinamide Mononucleotide Pubmed , Nmn Supplement 250mg , Nadph E Nadp+ , Our products are regularly supplied to many Groups and lots of Factories. Meanwhile, our products are sold to the USA, Italy, Singapore, Malaysia, Russia, Poland, and the Middle East.
High definition Morosil Com Nadh - Transaminase (ATA) – SyncoZymes Detail:

Enzymes: Are macromolecular biological catalysts, most enzymes are proteins.

Transaminases: A class of enzymes that catalyze amino transferring between amino acids and keto acids. Transaminases are key biological enzymes in asymmetric synthesis and racemic resolution of chiral amines.
Aminotransferase can be divided into four classes according to sequence and structure: Ⅰ, Ⅱ, Ⅲ and Ⅳ. ω-aminotransferases belong to class II transaminases, commonly be used in the preparation of chiral amines and unnatural amino acids, such as β-amino acids.

ω-aminotransferases: In most cases, ω-transaminase refers to a class of enzymes, that catalytic ammonia transfer reactions without α-amino acid as substrate or product.

Catalytic mechanism:

Transaminase ATA1

Enzymes Product Code Product Code
Enzyme Powder ES-ATA-101~ ES-ATA-165 a set of 65 ω-Transaminases, 50 mg each 65 items * 50mg / item, or other quantity
Screening Kit (SynKit) ES-ATA-6500 a set of 65 ω-Transaminases, 1 mg each 65 items * 1mg / item

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion efficiency.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Enzyme screening should be carried out for specific substrates because of the substrate specificity, and get an enzyme that catalyzes the target substrate with best catalytic effect.
➢ Never contact with extreme conditions such as: high temperature, high/low pH and organic solvent with high concentration.
➢ Normally, the reaction system should include substrate, buffer solution, amino donor (such as amino acids and 1-phenyl ethylamine) or receptor (such as keto acids), coenzyme (PLP), cosolvent (such as DMSO).
➢ ATA should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
➢ All kinds of ATA have various optimum reaction conditions, so each of them should be further studied individually.

Example 1(synthesis of Sitagliptin, asymmetric synthesis) (1):

Transaminase ATA2

Example 2 (Mexiletine, Combination of kinetic resolution with asymmetric synthesis)(2):

Transaminase ATA3

1 Savile CK, Janey JM, Mundorff EC, et al. Science, 2010, 329(16), 305-309.
2 Koszelewski D, Pressnitz D, Clay D, et al. Organic letters, 2009,11(21):4810-4812.


Product detail pictures:

High definition Morosil Com Nadh - Transaminase (ATA)  – SyncoZymes detail pictures


Related Product Guide:

Persisting in "High quality, Prompt Delivery, Competitive Price", we have established long-term cooperation with clients from both overseas and domestically and get new and old clients' high comments for High definition Morosil Com Nadh - Transaminase (ATA) – SyncoZymes , The product will supply to all over the world, such as: Argentina, belarus, Austria, Welcome to visit our company and factory, there are various products displayed in our showroom that will meet your expectation, meanwhile, if you are convenient to visit our website, our sales staff will try their efforts to provide you the best service
  • High production efficiency and good product quality, fast delivery and completed after-sale protection, a right choice, a best choice.
    5 Stars By Arabela from European - 2017.09.29 11:19
    This supplier's raw material quality is stable and reliable, has always been in accordance with the requirements of our company to provide the goods that quality meet our requirements.
    5 Stars By Tony from Pretoria - 2018.06.21 17:11
    Write your message here and send it to us