New Delivery for Mitochondrial Nadph - Transaminase (ATA) – SyncoZymes
New Delivery for Mitochondrial Nadph - Transaminase (ATA) – SyncoZymes Detail:
Enzymes: Are macromolecular biological catalysts, most enzymes are proteins.
Transaminases: A class of enzymes that catalyze amino transferring between amino acids and keto acids. Transaminases are key biological enzymes in asymmetric synthesis and racemic resolution of chiral amines.
Aminotransferase can be divided into four classes according to sequence and structure: Ⅰ, Ⅱ, Ⅲ and Ⅳ. ω-aminotransferases belong to class II transaminases, commonly be used in the preparation of chiral amines and unnatural amino acids, such as β-amino acids.
ω-aminotransferases: In most cases, ω-transaminase refers to a class of enzymes, that catalytic ammonia transfer reactions without α-amino acid as substrate or product.
Catalytic mechanism:
Enzymes | Product Code | Product Code |
Enzyme Powder | ES-ATA-101~ ES-ATA-165 | a set of 65 ω-Transaminases, 50 mg each 65 items * 50mg / item, or other quantity |
Screening Kit (SynKit) | ES-ATA-6500 | a set of 65 ω-Transaminases, 1 mg each 65 items * 1mg / item |
★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion efficiency.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Enzyme screening should be carried out for specific substrates because of the substrate specificity, and get an enzyme that catalyzes the target substrate with best catalytic effect.
➢ Never contact with extreme conditions such as: high temperature, high/low pH and organic solvent with high concentration.
➢ Normally, the reaction system should include substrate, buffer solution, amino donor (such as amino acids and 1-phenyl ethylamine) or receptor (such as keto acids), coenzyme (PLP), cosolvent (such as DMSO).
➢ ATA should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
➢ All kinds of ATA have various optimum reaction conditions, so each of them should be further studied individually.
Example 1(synthesis of Sitagliptin, asymmetric synthesis) (1):
Example 2 (Mexiletine, Combination of kinetic resolution with asymmetric synthesis)(2):
1 Savile CK, Janey JM, Mundorff EC, et al. Science, 2010, 329(16), 305-309.
2 Koszelewski D, Pressnitz D, Clay D, et al. Organic letters, 2009,11(21):4810-4812.
Product detail pictures:
Related Product Guide:
We can constantly satisfy our respected customers with our good high quality, good price tag and good support due to we have been additional specialist and extra hard-working and do it in cost-effective way for New Delivery for Mitochondrial Nadph - Transaminase (ATA) – SyncoZymes , The product will supply to all over the world, such as: Nicaragua, Ecuador, Macedonia, The products has a good reputation with competitive price, unique creation, leading the industry trends. The company insists on the principle of win-win idea, has establishedglobal sales network and after-sales service network.
By Karen from kazakhstan - 2017.08.18 18:38
Hope that the company could stick to the enterprise spirit of "Quality, Efficiency, Innovation and Integrity", it will be better and better in the future.
By Ada from Nicaragua - 2018.12.05 13:53