β-Nicotinamide adenine dinucleotide phosphate hydrate (NADP)
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| Chemical Name | β-Nicotinamide adenine dinucleotide phosphate hydrate |
| Synonyms | β-Nicotinamide adenine dinucleotide phosphate hydrate |
| CAS Number | 53-59-8 |
| Molecular Weight | 743.41 |
| Molecular Formula | C21H28N7O17P3 |
| EINECS No. | 200-178-1 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: 50 mg/mL, clear, slightly yellow |
| pka | pKa1 3.9; pKa2 6.1(at 25℃) |
| λmax | 260nm(lit.) |
| Merck | 14,6348 |
| EPA Substance Registry System | Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-59-8) |
| Test Item | Specifications |
| Appearance | White to yellow powder |
| Solubility | 200mg/ml in water |
| pH value (100mg/ml) | 5.0～7.0 |
| UV Spectral Analysis εat 260 nm and pH 7.5 |
(18±1.0)×10³L/mol/cm |
| Content (by enzymatic analysis with G6PDH at pH 7.5, using spectrophotometer, abs.340nm, on anhydrous basis) | ≥90.0% |
| Purity (by HPLC, %area) | ≥95.0% |
| Water content (by KF) | ≤5% |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep tightly stoppered in dark, for prolonged storage keep at 2~8℃.
NADP is a coenzyme, which is a substance in which nicotinamide adenine dinucleotide and a phosphate molecule are bound by an ester bond, and widely exists in the biological world. Its chemical properties, absorption spectrum, redox form, etc. are similar to NAD (Coenzyme I). NADP can be widely used in reactions catalyzed by various alcohol dehydrogenases, ketoreductases and other oxidoreductases. Such as: it can be reduced to NADPH by many dehydrogenases such as 6-phosphoglucose dehydrogenase (EC.1.1.1.49), 6-phosphogluconate dehydrogenase (EC.1.1.1.44). However, it is not necessarily able to react with many dehydrogenases that utilize NAD, nor can it be directly oxidized by the respiratory chain. Unlike NAD, it exists mainly in a reduced state in the cells of aerobic organisms.
According to product use, it can be divided into the following grades: biotransformation grade, diagnostic reagent grade,health food grade.
Biotransformation grade: It can be used for the synthesis of pharmaceutical intermediates and APIs, mainly with catalytic enzymes, such as ketoreductase (KRED), P450 monooxygenase (CYP), formate dehydrogenase (FDH), glucose dehydrogenase (GDH), etc. Wait.
Diagnostic reagent grade: With a variety of diagnostic enzymes, as the raw material of diagnostic kits.
Health food grade: The dietary supplement application of NADP is mainly in the research and development process.
