SyncoZymes

products

OEM Manufacturer Nicotinamide Mononucleotide Formula - Transaminase (ATA) – SyncoZymes

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Bear "Customer initially, High-quality first" in mind, we work closely with our prospects and supply them with efficient and specialist companies for Nicotinamide Mono , Nicotinamide Mononucleotide Nad , Best Nicotinamide Riboside Supplement , You may find the lowest price here. Also you will get high quality products and excellent service here! Please do not hesitate to contact us!
OEM Manufacturer Nicotinamide Mononucleotide Formula - Transaminase (ATA) – SyncoZymes Detail:

Enzymes: Are macromolecular biological catalysts, most enzymes are proteins.

Transaminases: A class of enzymes that catalyze amino transferring between amino acids and keto acids. Transaminases are key biological enzymes in asymmetric synthesis and racemic resolution of chiral amines.
Aminotransferase can be divided into four classes according to sequence and structure: Ⅰ, Ⅱ, Ⅲ and Ⅳ. ω-aminotransferases belong to class II transaminases, commonly be used in the preparation of chiral amines and unnatural amino acids, such as β-amino acids.

ω-aminotransferases: In most cases, ω-transaminase refers to a class of enzymes, that catalytic ammonia transfer reactions without α-amino acid as substrate or product.

Catalytic mechanism:

Transaminase ATA1

Enzymes Product Code Product Code
Enzyme Powder ES-ATA-101~ ES-ATA-165 a set of 65 ω-Transaminases, 50 mg each 65 items * 50mg / item, or other quantity
Screening Kit (SynKit) ES-ATA-6500 a set of 65 ω-Transaminases, 1 mg each 65 items * 1mg / item

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion efficiency.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Enzyme screening should be carried out for specific substrates because of the substrate specificity, and get an enzyme that catalyzes the target substrate with best catalytic effect.
➢ Never contact with extreme conditions such as: high temperature, high/low pH and organic solvent with high concentration.
➢ Normally, the reaction system should include substrate, buffer solution, amino donor (such as amino acids and 1-phenyl ethylamine) or receptor (such as keto acids), coenzyme (PLP), cosolvent (such as DMSO).
➢ ATA should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
➢ All kinds of ATA have various optimum reaction conditions, so each of them should be further studied individually.

Example 1(synthesis of Sitagliptin, asymmetric synthesis) (1):

Transaminase ATA2

Example 2 (Mexiletine, Combination of kinetic resolution with asymmetric synthesis)(2):

Transaminase ATA3

1 Savile CK, Janey JM, Mundorff EC, et al. Science, 2010, 329(16), 305-309.
2 Koszelewski D, Pressnitz D, Clay D, et al. Organic letters, 2009,11(21):4810-4812.


Product detail pictures:

OEM Manufacturer Nicotinamide Mononucleotide Formula - Transaminase (ATA)  – SyncoZymes detail pictures


Related Product Guide:

Good quality comes 1st; assistance is foremost; business enterprise is cooperation" is our business enterprise philosophy which is regularly observed and pursued by our company for OEM Manufacturer Nicotinamide Mononucleotide Formula - Transaminase (ATA) – SyncoZymes , The product will supply to all over the world, such as: Salt Lake City, Rotterdam, Niger, With a fully integrated operation system, our company has won a good fame for our high quality products, reasonable prices and good services. Meanwhile, we have established a strict quality management system conducted in material incoming, processing and delivery. Abiding by the principle of "Credit first and customer supremacy", we sincerely welcome clients from home and abroad to cooperate with us and advance together to create a brilliant future.
  • Timely delivery, strict implementation of the contract provisions of the goods, encountered special circumstances, but also actively cooperate, a trustworthy company!
    5 Stars By Jamie from Holland - 2017.01.28 19:59
    In China, we have many partners, this company is the most satisfying to us, reliable quality and good credit, it is worth appreciation.
    5 Stars By Frederica from Israel - 2017.07.28 15:46
    Write your message here and send it to us