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Phenylalanine dehydrogenase (PDH)

Short Description:

About Phenylalanine dehydrogenase

ES-PDH: A class of oxidoreductase. The positive reaction can catalyze the oxidative deamination of L phenylalanine salt in the presence of NAD to produce phenylpyruvate salt, and the reverse reaction can catalyze the synthesis of corresponding amino acid salt from phenylpyruvate salt. Syncozymes developed 8 items of phenylalanine dehydrogenase (numbered ES-PDH-101~ES-PDH-108). ES-PDH can be used to prepare phenylalanine salt or corresponding amino acid salt from phenylpyruvic acid salt or derivatives.
Catalytic reaction type:

PDH2

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E-Mail: lchen@syncozymes.com


Product Detail

Product Tags

Product Information:

PDH
Enzymes Product Code Specification
Enzyme Powder ES-PDH-101~ ES-PDH-108 a set of 8 Nitrile Reductase, 50 mg each 8 items * 50mg / item, or other quantity

Advantages:

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

Instructions for use:

➢ Normally, the reaction system should include substrate, buffer solution, enzyme, coenzyme (NAD(H)), coenzyme regeneration system (e.g. ammonium formate and formate dehydrogenase).
➢ Each kind of ES-PDH corresponding to various optimum reaction conditions, which could be studied individually if needed.
➢ The ES-PDH should be added last into reaction system to maintain the activity.

Application Examples:

Example 1(Biosynthesis of phenylalanine derivatives from phenylpyruvate derivatives)(1):

PDH3

Storage:

Keep 2 years below -20℃.

Attention:

Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.

References:

1. Francesca Paradisi, Stuart Collins, et al. Journal of Biotechnology, 2007, 128, 408–411.


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