Renewable Design for Nicotinamide Mononucleotide Vitamin B3 - Aldolase (DERA) – SyncoZymes

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Renewable Design for Nicotinamide Mononucleotide Vitamin B3 - Aldolase (DERA) – SyncoZymes Detail:

There are 8 kinds of aldolase products (Number as ES-DERA-101～ES-DERA-108) developed by SyncoZymes. SZ-DERA is a useful tool to catalyze enantioselective carbon-carbon bond formation, generating up to two chiral centers under mild reaction conditions.

Catalytic reaction type:

Catalytic reaction1

Catalytic mechanism:

Catalytic mechanism
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Enzymes	Product Code	Specification
Enzyme Powder	ES-DERA-101~ ES-DERA-108	a set of 8 Aldolase, 50 mg each 8 items * 50mg / item, or other quantity
Screening Kit (SynKit)	ES-DERA-800	a set of 8 Aldolase, 1 mg each 8 items * 1mg / item

★ Broad substrate spectrum.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Normally, the reaction system should include substrate, buffer solution (optimum reaction pH) and the ES-DERA.
➢ All kinds of ES-DERAs corresponding to various optimum reaction conditions should be studied individually.
➢ The ES-DERA should be added last into reaction system to maintain the activity.
➢ High concentration Substrate or product with may inhibit ES-DERA’s activity. However, the inhibition can be relieved by batch addition of substrate.

Example 1 ⁽¹⁾:

Example

Keep 2 years below -20℃.

Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.

1. Haridas M, Abdelraheem E, Hanefeld U, e tal. Appl Microbiol Biot, 2018, 102, 9959–9971.

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