Renewable Design for Nicotinamide Mononucleotide Vitamin B3 - Imine reductase (IRED) – SyncoZymes

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Renewable Design for Nicotinamide Mononucleotide Vitamin B3 - Imine reductase (IRED) – SyncoZymes Detail:

Imine reductase (IRED)

Enzymes	Product Code	Specification
Enzyme Powder	ES-IRED-101~ ES-IRED-114	a set of 14 Imine Reductase, 50 mg each
96-Well Enzyme Screening Kit	ES-IRED-1400	a set of 14 Imine Reductase, 1 mg each

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Normally, the reaction system should include substrate, buffer solution, enzyme, coenzyme, and coenzyme regeneration system.
➢ All kinds of ES-IREDs corresponding to various optimum reaction conditions should be studied individually.
➢ High concentration Substrate or product with may inhibit ES-IRED’s activity. However, the inhibition can be relieved by batch addition of substrate.

Example 1(Biosynthesis of chiral 2-methyl pyrrolidine)⁽¹⁾:

Imine reductase (IRED)3

Example 2(Biosynthesis of secondary amine)⁽²⁾:

Imine reductase (IRED)4

Example 3 (Reduction of Cyclic Imines)⁽³⁾:

Imine reductase (IRED)5

Keep 2 years below -20℃.

Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.

1. Scheller PN, Fademrecht S, Hofelzer S, et al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, et al. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al. Adv. Synth. Catal. 2015, 357, 1692-1696.

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